Rearrangement of 4‑Amino-3-halo-pyridines by Nucleophilic Aromatic Substitution
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https://figshare.com/articles/dataset/Rearrangement_of_4_Amino_3_halo_pyridines_by_Nucleophilic_Aromatic_Substitution/2407606
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资源简介:
The
reaction of 3-halo-4-aminopyridines with acyl chlorides and
triethylamine is described. The pyridin-4-yl α-substituted acetamide
products were obtained in moderate to high yields. The presented rearrangement
reaction, in which the presumed N-acylated intermediate
reacts intramolecularly via nucleophilic aromatic substitution, results
in a formal two-carbon insertion.
创建时间:
2016-02-19



