Treatment Naïve and Follow-Up Pediatric Ulcerative Colitis Rectal Gene Expression

PROTECT is a multicenter pediatric inception cohort study of response to standardized colitis therapy. In order to more explicitly model progression to colectomy within one year of diagnosis, we performed differential expression analysis between baseline rectal RNAseq biopsies of 21 patients who progressed to colectomy, and 310 who did not. We report rectal gene expression of pediatric patients with ulcerative colitis at diagnosis and at one year follow-up. 418 rectal biopsies were obtained from pediatric ulcerative colitis patients during colonoscopy. Transcriptome profiling was performed with RNA-Seq.