Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist RTI-3a

Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist RTI-3a Descriptor: (2~{S})-2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]-4-methyl-pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1),Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1) Authors: Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. Deposit date: 2020-06-05 Release date: 2021-02-10 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021

与小分子部分激动剂RTI-3a结合的神经降压素受体1（Neurotensin receptor 1, NTSR1）的晶体结构。描述符：(2S)-2-[[1-(7-氯喹啉-4-基)-5-(2,6-二甲氧基苯基)吡唑-3-基]羰基氨基]-4-甲基戊酸、神经降压素1型受体、神经降压素1型受体、神经降压素受体1（NTSR1）、神经降压素受体1（NTSR1）、神经降压素1型受体、神经降压素受体1（NTSR1）、神经降压素受体1（NTSR1）。作者：Deluigi M、Klipp A、Hilge M、Merklinger L、Klenk C、Plueckthun A。沉积日期：2020-06-05；发布日期：2021-02-10；最后修改日期：2024-10-16。实验方法：X射线衍射（2.72埃）。引用文献：《与小分子配体结合的神经降压素受体1复合物揭示完全激动、部分激动及反向激动的结构决定因素》，Science Advances，7卷，2021年。