Transporter Classification Database
收藏资源简介：
This freely accessible database details a comprehensive IUBMB approved classification system for membrane transport proteins known as the Transporter Classification (TC) system. The TC system is analogous to the Enzyme Commission (EC) system for classification of enzymes, except that it incorporates both functional and phylogenetic information for organisms of all types. As of September 15, 2024, TCDB consists of 23,736 proteins classified in 18,604 transport systems with 1,603 tabulated 3D structures, 24,411 reference citations describing 1,956 transporter families, of which 25% are members of 108 recognized superfamilies. The most recent update of the database contents and features include (1) adoption of a chemical ontology for substrates of transporters, (2) inclusion of new superfamilies, (3) a domain-based characterization of transporter families (tcDoms) for the identification of new members as well as functional and evolutionary relationships between families, (4) development of novel software to facilitate curation and use of the database, (5) addition of new subclasses of transport systems including 11 novel types of channels and 3 types of group translocators, and (6) the inclusion of many man-made (artificial) transmembrane pores/channels and carriers.
本免费开放获取数据库详细介绍了一套经国际生物化学与分子生物学联合会（International Union of Biochemistry and Molecular Biology, IUBMB）认可的膜转运蛋白分类系统，即转运蛋白分类（Transporter Classification, TC）系统。该TC系统与用于酶分类的酶学委员会（Enzyme Commission, EC）系统类似，不同之处在于它整合了所有类型生物的功能与系统发育信息。截至2024年9月15日，TCDB共收录23736个蛋白质，归类于18604个转运系统，包含1603个已制表的三维结构；另有24411篇参考文献阐释了1956个转运蛋白家族，其中25%的家族隶属于108个已确认的超家族。该数据库近期的内容与功能更新包括：（1）为转运蛋白底物采用了化学本体论；（2）新增了超家族；（3）推出了基于结构域的转运蛋白家族表征工具（tcDoms），用于识别新家族成员及解析家族间的功能与进化关联；（4）开发了全新软件以简化数据库的管理与使用；（5）新增了转运系统的新子类，包括11种新型通道以及3种基团移位转运体；（6）收录了大量人造（人工）跨膜孔道/通道与转运载体。
