Histamine and collagen regulation within the wound

Collagen accumulation in wounds is regulated by inflammatory mediators. An adequate inflammatory reaction influences deposition of that protein within granulation tissue of the wounds. The aim of the present study is to check whether histamine my influence collagen deposition acting directly on myofibroblasts derived from granulation tissue of the wound. Moreover, we plan on identifying the histamine receptor involved in this process.

伤口中胶原蛋白的积累受炎症介质的调控。适当的炎症反应影响该蛋白在伤口肉芽组织中的沉积。本研究旨在探讨组胺是否能够直接作用于源自伤口肉芽组织的肌成纤维细胞，从而影响胶原蛋白的沉积。此外，我们计划鉴定出参与此过程的组胺受体。