Tolerogenic IL-10-engineered dendritic cell-based therapy to restore antigen-specific tolerance in T cell mediated diseases

In the manuscript "Tolerogenic IL-10-engineered dendritic cell-based therapy to restore antigen-specific tolerance in T cell mediated diseases" published in Journal of Autoimmunity on May 22 2023 (doi: 10.1016/j.jaut.2023.103051). We describe the in vitro generation of dendritic cells genetically modified to render them pro-tolerogenic and able to modulate unwanted immune responses to auto-antigens both in vitro and in vivo. Raw data for each main figure published in the manuscript are available in the relative.csv file. Read the Read_me.rtf file for more details and for the accession numbers of NGS data deposited at GEO.本研究内容出自2023年5月22日发表于《自身免疫杂志（Journal of Autoimmunity）》（doi: 10.1016/j.jaut.2023.103051）的论文《基于白细胞介素10（IL-10）工程化树突状细胞的耐受性疗法，用于恢复T细胞介导疾病中的抗原特异性免疫耐受》（Tolerogenic IL-10-engineered dendritic cell-based therapy to restore antigen-specific tolerance in T cell mediated diseases）。本研究阐明了经基因修饰以获得致耐受性表型、并可在体外及体内调控针对自身抗原的异常免疫应答的树突状细胞的体外制备方案。论文中所有主图对应的原始数据均可在对应.csv文件中获取。如需获取更多细节信息，以及存放在基因表达数据库（Gene Expression Omnibus, GEO）中的下一代测序（Next-Generation Sequencing, NGS）数据登录号，请查阅Read_me.rtf文件。