PI3 kinase delta in complex with 5-(3,6-dihydro-2H-pyran-4-yl)-2-methoxy-N-(5-{3-[4-(propan-2-yl)piperazin-1-yl]prop-1-yn-1-yl}pyridin-3-yl)pyridine-3-sulfonamide

PI3 kinase delta in complex with 5-(3,6-dihydro-2H-pyran-4-yl)-2-methoxy-N-(5-{3-[4-(propan-2-yl)piperazin-1-yl]prop-1-yn-1-yl}pyridin-3-yl)pyridine-3-sulfonamide Descriptor: 5-(3,6-dihydro-2~{H}-pyran-4-yl)-2-methoxy-~{N}-[5-[3-(4-propan-2-ylpiperazin-1-yl)prop-1-ynyl]pyridin-3-yl]pyridine-3-sulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Authors: Rowland, P, Convery, M. Deposit date: 2021-09-09 Release date: 2021-09-29 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.493 Å) Cite: Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3K delta with a Novel Binding Mode. J.Med.Chem., 64, 2021

PI3激酶δ亚型（PI3 kinase delta）与5-(3,6-二氢-2H-吡喃-4-基)-2-甲氧基-N-(5-{3-[4-(异丙基)哌嗪-1-基]丙-1-炔-1-基}吡啶-3-基)吡啶-3-磺酰胺的复合物。
描述符：5-(3,6-二氢-2H-吡喃-4-基)-2-甲氧基-N-[5-[3-(4-异丙基哌嗪-1-基)丙-1-炔基]吡啶-3-基]吡啶-3-磺酰胺、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基δ亚型（Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform）
作者：Rowland, P、Convery, M.
沉积日期：2021-09-09
发布日期：2021-09-29
最后修改日期：2024-06-19
结构解析方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.493埃
引用文献：《GSK251的发现：一种具备新型结合模式的强效高选择性口服生物可利用PI3Kδ抑制剂》，《J. Med. Chem.》，64卷，2021年