WGS of peptaibol-resistant Plasmodium parasites

NIAID Data Ecosystem2026-05-01 收录

抗疟药物靶点鉴定

疟原虫抗性基因组学

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP362538 数据链接链接失效反馈

官方服务：

资源简介：

Target identification project for Harzianin, a peptaibol with antimalarial activity.

创建时间：

2024-04-01

Expression of Plasmodium major facilitator superfamily protein in transporters – Δ Candida identifies a drug transporter

抗疟药物靶点鉴定

疟原虫耐药机制

Aim: To assess the functional relevance of a putative Major Facilitator Superfamily protein (PF3D7_0210300; ‘PfMFSDT’) as a drug transporter, using Candida glabrata for orthologous protein expression.

NIAID Data Ecosystem60

Table_1_Characterization of a Sulfhydryl Oxidase From Plasmodium berghei as a Target for Blocking Parasite Transmission.docx

疟原虫传播

抗疟药物靶点鉴定

Quiescin sulfhydryl oxidase (QSOX), present in a wide variety of eukaryotic species, catalyzes the insertion of disulfide bonds into unfolded, reduced proteins. Here we characterized the QSOX protein

NIAID Data Ecosystem30

Primers used in this study.

疟原虫离子通道

抗疟药物靶点鉴定

Malaria parasites survive in human erythrocytes by importing and digesting hemoglobin within a specialized organelle, the digestive vacuole (DV). Although chloroquine and other antimalarials act withi

NIAID Data Ecosystem20

WGS of Plasmodium falciparum selected with AcAS inhibitors

抗疟药物靶点鉴定

PfAcAS抑制剂研究

These Plasmodium falciparum samples have been in vitro selected with antimalarial compounds MMV019721 and MMV084978 as part of a drug target identification study in the MalDA Consortium. Based on thes

NIAID Data Ecosystem40

WGS of peptaibol-resistant Plasmodium parasites

抗疟药物靶点鉴定

癌症耐药机制研究

Target identification project for Harzianin, a peptaibol with antimalarial activity.

NIAID Data Ecosystem20