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Assessement of transcriptional consequences of CD27 signaling on Tregs during Th17 polarization

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NIAID Data Ecosystem2026-05-26 收录
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The goal of this study was to identify transcripts that were differentially expressed in untreated vs FcCD70 treated Tregs cultured in Th17 promoting conditions. Overall design: Tregs were sort purified from FOXP3-GFP reporter mice and cultured with anti-CD3/anti-CD28 coated Dynalbeads in Th17-polarizing conditions in the presence or absence of FcCD70. On day 6 we performed whole transcriptome RNAseq on purified cells.

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2018-12-03
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