2000HIV plasma proteome

In this collection, you can find the circulating plasma protein expression of 2932 proteins measured in 1930 samples from the 2000HIV cohort. In addition, you can find the metadata that accompany the following study by Otten et al, “Impact of COVID-19, Lockdowns and Vaccination on Immune Responses in a HIV cohort in the Netherlands; Front. Immunol 15-2024; doi: 10.3389/fimmu.2024.1459593”.

The 2000HIV study is a prospective longitudinal cohort study of people living with HIV (PLHIV) on cART. It aims to discover new biological pathways and identify biomarkers that play a role in persistent inflammation, accelerated ageing, non-AIDS co-morbidities, extreme HIV-related clinical phenotypes (Elite controllers, immunological non-responders, and rapid progressors) and the HIV viral reservoir size and composition. To this end, 1895 PLHIV, divided into two independent cohorts (a discovery and validation cohort), recruited between 2019 and 2021, and followed-up for two years. Extensive clinical data and measurements were registered, multi-omics data were generated, and the latent viral reservoir size and composition were assessed in this cohort.