Interactions by protein function.

Interactions by protein function based on the connectivity with the tumor tissue signatures and with proteins from the human proteome MetaCore database. The proteins were considered over-connected when the number of observed interactions exceeded the number of expected interactions. Actual: number of network objects in the signature which interact with the chosen object; n: number of network objects in the signature; R: number of network objects in the background list which interact with the chosen object; N: total number of protein-based objects in the background list; Expected: mean of hypergeometric distribution. Ratio: connectivity ratio (Actual/Expected); z-score: (Actual-Expected)/(standard deviation); p-value: probability to have the value of Actual or higher (lower for negative z-score) by chance under null hypothesis of no over- or under-connectivity.
Interactions by protein function.