Ru-Catalyzed Deoxygenative Regioselective C8–H Arylation of Quinoline <i>N</i>‑Oxides
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Regioselective C–H functionalization on quinolines is of high interest to lead to value-added products. Herein, we describe the development of Ru-catalyzed deoxygenative regioselective C8 arylation of quinoline N-oxides with arylboronic esters. Mechanistic studies revealed that it proceeds in a tandem process of arylation and then deoxygenation, wherein both steps were found to be catalytic with the ruthenium species.
创建时间:
2019-07-19



