Statin-induced microRNAome alterations in patients with hypercholesterolemia

This study investigates miRNA expression profiles from peripheral blood specimens in patients with hypercholesterolemia. Our findings demonstrated that miRNA regulations could be involved in statin-induced inflammation modulation in immune cells, thereby providing an anti-inflammatory approach to reduce residual ASCVD risk in individuals with optimal lipid control. A total of 34 hypercholesterolemic patients were recruited to receive 2 mg/day pitavastatin or 10 mg/day atorvastatin treatment for 12 weeks. Peripheral blood mononuclear cells (PBMC) were isolated at enrollment and 12 weeks.