Multiple micronutrient status and predictors of anemia in young children aged 12-23 months living in New Delhi, India

Anemia has been identified as a severe public health concern among young children in India, however, information on the prevalence of anemia attributed to micronutrient deficiencies is lacking. We aimed to assess multiple micronutrient status (iron, zinc, selenium, vitamin A, vitamin D, folate and vitamin B12) in young Indian children and to investigate the role of these seven micronutrients and other non-nutritional factors on hemoglobin concentrations and anemia. One-hundred and twenty children aged 12 to 23 months were included in a cross-sectional nutritional assessment survey, of which 77 children provided a blood sample. Hemoglobin (Hb), serum ferritin, soluble transferrin receptor (sTfR), total body iron, zinc, selenium, retinol binding protein (RBP), folate, vitamin B12 and 25-hydroxyvitamin D (25(OH)D) were measured, and adjusted for inflammation using C-reactive protein (CRP) and α-1-acid glycoprotein (AGP), where appropriate. Predictors for hemoglobin and anemia were identifi...贫血已被认定为印度幼儿面临的一项严重公共卫生问题，但目前仍缺乏由微量营养素缺乏引发的贫血患病率相关数据。本研究旨在评估印度幼儿的多种微量营养素营养状况，涉及铁、锌、硒、维生素A、维生素D、叶酸及维生素B12共七种微量营养素，并探究上述营养素与其他非营养因素对血红蛋白浓度及贫血的影响。本次横断面营养评估调查共纳入120名12~23月龄的幼儿，其中77名幼儿提供了血液样本。检测指标包括血红蛋白（Hemoglobin, Hb）、血清铁蛋白、可溶性转铁蛋白受体（soluble transferrin receptor, sTfR）、总体铁含量、锌、硒、视黄醇结合蛋白（retinol binding protein, RBP）、叶酸、维生素B12及25-羟维生素D（25-hydroxyvitamin D, 25(OH)D）；并在适宜情况下，利用C反应蛋白（C-reactive protein, CRP）与α-1-酸性糖蛋白（α-1-acid glycoprotein, AGP）对炎症状态进行校正。本研究将对血红蛋白与贫血的预测因素进行识别……