PLA2G12B

The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

该基因编码的蛋白质属于磷脂酶A2（PLA2）酶类家族，此类酶类在糖脂水解过程中释放游离脂肪酸和溶血磷脂。本家族成员具有改变磷脂结合特性的特征，且催化活性丧失。该蛋白质被分泌，并与微体甘油三酯转移蛋白协同作用，以调节HNF4alpha诱导的丙型肝炎病毒感染活性。该基因的表达在各种肿瘤中被下调，提示其可能作为肿瘤进展的负调节因子发挥作用。该基因的剪接变异导致多种转录本的产生。[由RefSeq提供，2015年12月]