A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance

To further explore the molecular characteristics of these formed cCSCs, mRNA profile analysis was performed and compared between cCSCs and the corresponding adherent cells. Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of2 different cells at two forms(adherent and spheroids ). Comparative gene expression profiling analysis of RNA-seq data for HCT116 and LOVO cells and their different forms.