Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode I)

Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode I) Descriptor: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... Authors: Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. Deposit date: 2023-05-12 Release date: 2023-06-21 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023

存在LY341495与NAM563时的mGlu2-mGlu3异二聚体冷冻电子显微镜（Cryo-EM）结构（二聚化模式I）。配体描述：2-[(1S,2S)-2-羧基环丙基]-3-(9H-氧杂蒽-9-基)-D-丙氨酸、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、胆固醇……。作者：Wang, X、Wang, M、Xu, T、Feng, Y、Han, S、Lin, S、Zhao, Q、Wu, B。提交日期：2023-05-12。发布日期：2023-06-21。最后修改日期：2024-10-30。实验方法：电子显微镜（3 Å）。引用文献：《mGlu2-mGlu3与mGlu2-mGlu4异二聚体的二聚化与激活的结构洞察》，《细胞研究》（Cell Res.），第33卷，2023年。