Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury [scRNA-seq]

Here we profile the transcripts of app. 35.000 single cells isolated from livers of healthy and diseased mice. We show the transcriptomic change associated with fibrosis induction in the non-parenchymal cell types (hepatic stellate cells, liver endothelial cells and macrophages). We reveal a hitherto unknown feature of the HSCs otherwise functionally attributed to the LECs. Overall design: 10x Genomics single-cell transcriptomic data of isolated non-parenchymal liver cells from healthy and diseased (2w and 4w CCl4 treated) mice.