Identifying convergent pathomechanisms in ALS using hiPSC-derived motor neurons

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly affecting upper and lower motoneurons (MNs). In the last decades, several genes have been associated to the familial form of this disorder (fALS), thus depicting an extremely complex pathogenic landscape. The aim of this study was to identify convergent molecular underpinnings shared by ALS cases characterized by mutations in different genes using human induced pluripotent stem cells (hiPSCs).