Crystal structure of human cyclophilin D (CypD) with in complex with the covalently bound Ebselen inhibitor

Crystal structure of human cyclophilin D (CypD) with in complex with the covalently bound Ebselen inhibitor Descriptor: N-phenyl-2-selanylbenzamide, Peptidyl-prolyl cis-trans isomerase F, mitochondrial Authors: Lovell, S, Battaile, K.P, Yan, S. Deposit date: 2022-09-19 Release date: 2023-10-18 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.65 Å) Cite: New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease. Brain, 147, 2024人类亲环蛋白D（cyclophilin D, CypD）与共价结合的依布硒啉（Ebselen）抑制剂N-苯基-2-硒烷基苯甲酰胺（N-phenyl-2-selanylbenzamide）形成的复合物晶体结构，该蛋白为线粒体肽基脯氨酰顺反异构酶F（Peptidyl-prolyl cis-trans isomerase F, mitochondrial）。作者：Lovell S、Battaile K.P、Yan S。提交日期：2022-09-19，发布日期：2023-10-18，最后修改日期：2026-03-04。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.65埃（Å）。引用文献：《阿尔茨海默病中新型亲环蛋白D抑制剂可挽救线粒体与认知功能》，《Brain》，第147卷，2024年。