Inhibitors of Receptor Tyrosine Kinases reduce Arg1 transcription.

1Inhibitors (dissolved in DMSO) were used at twice the concentration reported to cause 50% inhibition of kinase activity.
No attempt was made to maximize concentration for complete kinase inhibition.
2Arg1 mRNA expression was determined in ex vivo cultured spleen cells from hamsters infected with L. donovani exposed to the RTK inhibitor for 24 hrs.
The percent inhibition of arg1 transcription was calculated with reference to untreated control cells exposed to DMSO and determined by qPCR.