Gene expression activation in CLL mediated by MSCs contact. Homo sapiens

Survival of primary CLL cells is mediated by mesenchimal stromal cells in vitro. The goal of this study is to compare the gene expression profile of primary CLL cells in monoculture to that one following cell-cell contact with MSCs Overall design: Primary CLL cells isolated from 6 different patients were cultured for 4h in normal growing medium or for 48h in coculture with EL08-1d1 cells