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The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes

NIAID Data Ecosystem2026-05-01 收录

急性髓系白血病表观遗传

KDM5C肿瘤抑制机制

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE141477 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-10-18

急性髓系白血病表观遗传

治疗反应预测

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The FDA-approved DNA hypomethylating agents (DHAs) like 5-azacytidine (5AC) and decitabine (DAC) demonstrate efficacy in the treatment of hematologic malignancies. Despite previous reports that showed

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Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

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The dysregulation of plant homeodomain (PHD) fingers has been implicated in several human diseases, including cancer. In a subset of aggressive acute myeloid leukemia (AML), chromosomal translocations

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Mediator kinase inhibition further activates super-enhancer-associated genes in AML

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增强子靶向治疗

Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded with the Mediator complex, transcription factors and chromatin regulators, drive high expression of genes implic

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Supplementary Table 7 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

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超级增强子与药物靶点分析

GO Analysis from Regions of Differential MOLM13 H3K27Ac CUT&Tag (6 Hours After Drug Treatment) Pileup at Enhancers and Promoters

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