Myc is required for adaptive beta cell replication in young mice but is not sufficient in one year old mice fed with a high fat
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Purpose: To test the role of Myc in adaptive expansion of beta cellsMethods: Islets were isolated from 8 week old or one year old male C57BL6 mice fed a standard or high fat diet. RNAseq and DNA mehtylseq was performed.Results: RNAseq showed that Myc target genes are upregulted in young, but not old mice after a short term high fat diet. DNA methylation analysis shows hypomethylation of cell cycle genes that are Myc targets in islets from young mice fed with a HFD. Importantly, DNA hypomethylation of Myc response elements does not occur in islets from one-year-old mice fed short-term HFDConclusions: We conclude that Myc is required for metabolic stress-mediated beta cell expansion in young mice, but with aging Myc upregulation in beta cells is not sufficient to induce beta cell replication by, at least partly, an epigenetically-mediated resistance to Myc action.
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MSSM
创建时间：
2022-02-20
