Circulating concentrations of progestins used in contraception

This dataset is a compilation of published progestin levels in blood plasma or serum, representing the circulating concentrations of progestins commonly used in contraception. The dataset consists of tables supplementary to the manuscript "Pharmacokinetics, metabolism and serum concentrations of progestins used in contraception", submitted to the journal Pharmacology & Therapeutics. In part of this manuscript we discuss possible reasons for the wide inter-individual and inter-study variability in reported serum progestin concentrations. The data was sourced through extensive PubMed searches for serum or plasma concentrations of progestins used in various methods of administration e.g. intramuscular injection, subdermal implant or combined oral contraceptive. The columns in these tables include progestin concentrations (in nanomolar[nM]/picomolar [pM] or nanograms/milliliter [ng/ml] or picograms/milliliter [pg/ml]) for several different progestins, the concentrations of endogenous estrogen or progesterone or exogenous ethinyl estradiol, the model system used (number of women, any other drugs used in combination, other demographics), the method of quantification used (typically radioimmunoassay [RIA] or liquid chromatography with mass spectrometry [LC-MS]) and the citation for the original reference (listed at the end of each table). Abbreviations are explained at the end of each table. Molecular weights used for concentration conversions between nM-ng/ml or pM-pg/ml are indicated at the end of each table. While organic solvent extraction is always used for LC-MS methods, it is sometimes used prior to RIA: where this information was available, the organic solvent used is reported. Some data may be omitted due to restricted access to the original publication. This is a non-exhaustive, manually compiled list from publications since the 1960s and as such, some mistakes and/or omissions may have unintentionally occurred.本数据集汇编了已发表的血浆或血清中孕激素水平数据，涵盖避孕临床常用孕激素的循环浓度。本数据集包含投稿至《Pharmacology & Therapeutics》期刊的论文 *Pharmacokinetics, metabolism and serum concentrations of progestins used in contraception* 的补充表格。该论文的部分章节探讨了已报道血清孕激素浓度存在显著个体间与研究间差异的潜在成因。 本数据集的数据通过全面的PubMed文献检索获取，检索范围覆盖不同给药方式（如肌内注射、皮下埋植、复方口服避孕药）下所用孕激素的血清或血浆浓度。 各补充表格的字段包括：多种孕激素的浓度（单位为纳摩尔[nM]/皮摩尔[pM]或纳克/毫升[ng/ml]或皮克/毫升[pg/ml]）、内源性雌激素、孕酮或外源性炔雌醇的浓度、所用研究模型信息（如受试者人数、联合使用的其他药物、其他人口统计学特征）、所用定量检测方法（通常为放射免疫分析法[radioimmunoassay, RIA]或液相色谱-质谱联用法[liquid chromatography with mass spectrometry, LC-MS]），以及原始参考文献的引用信息（各表格末尾列出）。 各表格末尾对所用缩写进行了解释说明；用于纳摩尔与纳克/毫升、皮摩尔与皮克/毫升之间浓度单位换算的分子量参数，也标注于各表格末尾。 尽管液相色谱-质谱联用法始终需要有机溶剂萃取步骤，但放射免疫分析法有时也会在检测前进行该预处理操作：若可获取相关信息，则会明确标注所用有机溶剂的种类。 由于部分原始文献存在获取限制，本数据集可能存在数据遗漏情况。本数据集为1960年代以来发表文献的手动汇编清单，并非完整全集，因此可能存在无意产生的疏漏或错误。