Data for: Safety evaluation of the venom from scorpion Rhopalurus junceus: assessment of oral short term, subchronic toxicity and teratogenic effect

Data for short-term, subchronic toxicity and the teratogenic potential of Rhopalurus junceus scorpion venom by oral route in mice. Short-term oral toxicity was test in both sexes NMRI mice that received 100 mg/kg/day of scorpion venom extract for 28 days. For the subchronic study, mice were administered with three doses (0.1, 10, and 100 mg/kg) by oral route for 90 days. Teratogenic potential was tested in pregnant mice administered from day 6 to 15 post conception. Significant differences were observed in body weight and food intake of animal treated for short-term and subchronic assays. Variations in serum urea and cholesterol were observed after 90 days oral treatment. Spontaneous findings not related to the treatment were reveal in histology evaluation. Exposure in pregnant mice did not produce maternal toxicity. Signs of embryo-fetal toxicity were not observed. The current study provides evidence that exposure to low or moderate dose of Rhopalurus junceus scorpion venom by oral route did not affect health of animals and has low impact on reproductive physiology.

本数据集收录了小鼠经口暴露朱毛蝎（Rhopalurus junceus）蝎毒后的短期毒性、亚慢性毒性及致畸潜能相关实验数据。短期经口毒性实验选用雌雄两性NMRI小鼠，以100 mg/kg/日的剂量灌胃蝎毒提取物，连续染毒28天。亚慢性毒性实验设置0.1、10、100 mg/kg三个剂量组，经口染毒小鼠，染毒周期为90天。致畸潜能实验则以受孕小鼠为对象，于妊娠第6至15天经口染毒开展测试。短期与亚慢性染毒实验中，受试小鼠的体重与食物摄入量均出现显著差异。经90天经口染毒后，受试小鼠血清尿素与胆固醇水平出现变化。组织病理学评估中观察到与染毒处理无关的自发性异常表现。妊娠小鼠经口染毒后未出现母体毒性，且未观察到胚胎-胎体毒性相关征象。本研究结果证实，经口暴露低或中等剂量的朱毛蝎蝎毒，不会对受试动物的健康造成影响，且对生殖生理功能的影响极低。