Crystal structure of the human METTL3-METTL14 in complex with compound 2 (T148)

Crystal structure of the human METTL3-METTL14 in complex with compound 2 (T148) Descriptor: 4-[[[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-phenyl]amino]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-4-ol, ACETATE ION, N(6)-adenosine-methyltransferase non-catalytic subunit METTL14, ... Authors: Bedi, R.K, Caflisch, A. Deposit date: 2025-06-30 Release date: 2026-03-18 Last modified: 2026-04-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Ligand-Induced Opening of a Cryptic Pocket in METTL14. Acs Bio Med Chem Au, 6, 2026人类METTL3-METTL14与化合物2（T148）结合的晶体结构 描述符：4-[[[4-[(4,4-二甲基哌啶-1-基)甲基]-2-羟基苯基]氨基]甲基]-1-[6-(苄基氨基)嘧啶-4-基]哌啶-4-醇、乙酸根、N⁶-腺苷甲基转移酶非催化亚基METTL14…… 作者：Bedi, R.K.、Caflisch, A. 存入日期：2025-06-30 发布日期：2026-03-18 最后修改日期：2026-04-29 实验方法：X射线衍射（分辨率2 Å） 引用文献：《配体诱导METTL14隐蔽口袋的开放》，Acs Bio Med Chem Au，6卷，2026年