Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(1H-indol-3-yl)acetamide

Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(1H-indol-3-yl)acetamide Descriptor: FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ... Authors: Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C. Deposit date: 2019-07-06 Release date: 2019-09-25 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode. J.Med.Chem., 62, 2019

结核分枝杆菌（Mycobacterium tuberculosis）延胡索酸水合酶（Fumarate hydratase）与甲酸以及变构调节剂N-(5-(氮杂环庚烷-1-基磺酰基)-2-甲氧基苯基)-2-(1H-吲哚-3-基)乙酰胺形成的复合物。描述项：甲酸、II类延胡索酸水合酶、镁离子（MAGNESIUM ION）等。作者：Whitehouse, A.J、Libardo, M.D、Kasbekar, M、Brear, P、Fischer, G、Thomas, C.J、Barry, C.E、Boshoff, H.I、Coyne, A.G、Abell, C。存入日期：2019-07-06；发布日期：2019-09-25；最后修改日期：2024-01-24。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.48埃（Å））。引用文献：《靶向结核分枝杆菌延胡索酸水合酶：采用具有二聚体结合模式的变构抑制剂》，J.Med.Chem., 62, 2019