Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor

Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor Descriptor: 5-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Barrack, K.L, Hunter, W.N. Deposit date: 2014-01-15 Release date: 2015-01-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014

布氏锥虫（Trypanosoma brucei）蝶啶还原酶1（Pteridine reductase 1, PTR1）与辅因子及抑制剂形成三元复合物的晶体结构。配体组成：5-苯乙基-7H-吡咯并[2,3-d]嘧啶-2,4-二胺、乙酸根离子（ACETATE ION）、烟酰胺腺嘌呤二核苷酸磷酸（NADP, Nicotinamide Adenine Dinucleotide Phosphate）。作者：Barrack, K.L.、Hunter, W.N.。存库日期：2014-01-15；发布日期：2015-01-21；最后修改日期：2023-12-20。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.9 Å）。引用文献：《靶向蝶啶还原酶1的抗寄生虫吡咯并嘧啶类化合物的基于结构设计与合成》，刊载于《药物化学杂志》（J. Med. Chem.）2014年第57卷。