TRIM21 is a molecular rheostat for influenza A virus replication

NIAID Data Ecosystem2026-05-10 收录

流感病毒复制调控

TRIM21基因功能

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP684765 数据链接链接失效反馈

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资源简介：

Transcriptomic analysis of WT and TRIM21-knockout A549 cells under mock and H1N1pdm09 infection conditions.

创建时间：

2026-03-18

Caspase cleavage of Influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production

病毒蛋白相互作用

流感病毒复制调控

Influenza A virus (IAV) Matrix 2 protein (M2) is an ion channel, required for efficient viral entry and egress. M2 interacts with the small ubiquitin-like LC3 protein through a cytoplasmic C-terminal

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Fig4B_RACE_YKT6_R1_AI9.tif

流感病毒复制调控

RNA降解分析

HEK293T ishXrn1 cells were treated with doxycycline for 3-4 days to induce knock down of Xrn1, then transfected with PA-X from the influenza A/Puerto Rico/8/1984 (H1N1) or vector, and luciferase repor

Figshare2023-01-19 更新20

Fig1B-C_qPCR_G6PD_HA_Xrn1ko_R1_LG258.xlsx

流感病毒复制调控

RT-qPCR基因表达分析

A549 Xrn1 knock-out cells were either mock infected, infected with WT influenza A/Puerto Rico/8/1934 (H1N1) virus ("PR8") or with PA-X deficient PR8-PA(∆X) for 16 hours before RNA extraction. mRNA lev

Figshare2023-01-19 更新10

Single-Cell RNA Analysis of Influenza A Virus infected MDCK cells

细胞病毒学

流感病毒复制调控

Virus replication displays a large cell-to-cell heterogeneity; yet, not all sources are known. Here, we study the effect of defective interfering (DI) particle (DIP) co-infection on cell-to-cell heter

NIAID Data Ecosystem40

Cellular hnRNP A2/B1 interacts with the NP of influenza A virus and impacts viral replication

流感病毒复制调控

病毒-宿主蛋白相互作用

The viral ribonucleoprotein (vRNP) of influenza A virus is formed by virion RNA (vRNA), viral polymerase complex, and nucleoprotein (NP). The NP plays an important role in facilitating the replication

NIAID Data Ecosystem20

TRIM21 is a molecular rheostat for influenza A virus replication

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