Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency.

Data from ProteomeXchange, PXD ID: PXD002150. File: 14july14_saha_b_65.mzml. Published as part of Antiviral Res. 2015 Sep 3. pii: S0166-3542(15)00213-2 . From the Abstract: {{i}} ... We therefore utilized a combined analysis of effects of SAHA on the host transcriptome and proteome to dissect its mechanisms of action that may explain its limited success in shock and kill strategies. CD4+ T cells from HIV seronegative donors were treated with 1 μM SAHA or its solvent dimethyl sulfoxide (DMSO) for 24 hours. Protein expression and post-translational modifications were measured with iTRAQ proteomics using ultra high-precision two-dimensional liquid chromatography - tandem mass spectrometry ... {{/i}}