PdCl2-Catalyzed Two-Component Cross-Coupling Cyclization of 2,3-Allenoic Acids with 2,3-Allenols. An Efficient Synthesis of 4-(1‘,3‘-Dien-2‘-yl)-2(5H)-furanone Derivatives

Cross-coupling cyclization reaction between 2,3-allenoic acids 1 and 2,3-allenols 2, in which two allenes functioned differently, was realized to afford 4-(1‘,3‘-dien-2‘-yl)-2(5H)-furanone derivatives 3. The reaction may proceed via an oxypalladation, insertion, and β-hydroxide elimination process. A high E-stereoselectivity of the new formed CC double bond was observed.

在2,3-艾伦酸1和2,3-艾伦醇2之间的跨偶联环化反应中，两种艾伦基团表现出不同的功能，成功合成了4-(1‘,3‘-二烯-2‘-基)-2(5H)-呋喃酮衍生物3。该反应可能通过氧膦化、插入和β-羟基消除的过程进行。新形成的C≡C双键表现出高E-立体选择性。