Crystal structure of IRE1a in complex with G-4100

Crystal structure of IRE1a in complex with G-4100 Descriptor: 4-amino-N-(6-chloro-2-fluoro-3-{[(pyrrolidin-1-yl)sulfonyl]amino}phenyl)quinazoline-8-carboxamide, SODIUM ION, Serine/threonine-protein kinase/endoribonuclease IRE1 Authors: Steinbacher, S, Wang, W. Deposit date: 2020-06-10 Release date: 2021-04-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1 alpha Inhibitory Activity. Acs Med.Chem.Lett., 11, 2020与G-4100结合的IRE1α晶体结构 描述项：4-氨基-N-(6-氯-2-氟-3-{[(吡咯烷-1-基)磺酰基]氨基}苯基)喹唑啉-8-甲酰胺、钠离子、丝氨酸/苏氨酸蛋白激酶/核糖核酸内切酶IRE1α 作者：Steinbacher, S.、Wang, W. 提交日期：2020-06-10 发布日期：2021-04-21 最后修改日期：2024-03-06 实验方法：X射线衍射（分辨率2.54 Å） 引用文献：《具有强效IRE1α抑制活性且规避BRaf的氨基噻吩并嘧啶类化合物的鉴定》，Acs Med.Chem.Lett., 11, 2020