Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice

Transgenic mice carrying the Arctic (E693G) and Swedish (KM670/6701NL) amyloid-b precursor protein (AβPP) develop amyloid-beta (Aβ) deposits in the brain that resemble Alzheimer’s disease neuropathology. The tg-ArcSwe atlas provides access to Aβx-40 immunolabeled histological section images from representative 12 month old tg-ArcSwe mice (Lord et al., Neurobiol. Aging 27:67-77, 2006), showing the morphology and spatial distribution of Aβx-40 plaque deposits across the brain. Analyses show that plaques are primarily distributed in the cerebral cortex, hippocampus, and thalamus. The average Aβ burden in the cortex and hippocampus is similar across animals, with coefficients of variance of 22% and 25%, respectively (Lillehaug et al., Neurobiol Aging 35:556-564, 2014).