Confirmed rabies in imported nonhuman primates.
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1confirmed by histological observation of Negri bodies in the brain.2confirmed by mouse inoculation with brain material.3confirmed by fluorescent antibody testing of brain samples.4This monkey had been vaccinated with a modified live-virus rabies vaccine of avian origin, 13 days before the onset of symptoms. The viral isolate from the rabid monkey had characteristics consistent with an egg-adapted vaccine strain suggesting that the monkey's infection was vaccine-induced. These included a short incubation period in mice (4–5 days), absence of fluorescent rabies antibodies detectable virus in salivary glands and corneas of the mice, only rare inclusions typical of Negri bodies produced on mouse passage, and high titered growth in eggs on first passage.5These monkeys had been vaccinated with a modified live-virus rabies vaccine (strain ERA) 43 and 28 days before the onset of the symptoms, suggesting that the monkey's infection was vaccine induced, although sequencing or typing were not done.6species not stated.
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2015-12-02



