BindingDB Entry 50025107: Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

Small molecule binding data for protein ALK tyrosine kinase receptor, Ephrin type-B receptor 4 (EphB4), Fibroblast growth factor receptor 1, Hepatocyte growth factor receptor, Insulin receptor, JAK2/TYK2, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, Lysyl-tRNA synthetase, Macrophage-stimulating protein receptor, Neurotrophic tyrosine kinase receptor type 2, Platelet-derived growth factor receptor beta, SRC, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BMX, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot L7RSL3, O60674, P00519, P06213, P07948, P07949, P08581, P09619, P11362, P12931, P15127, P17948, P29597, P35968, P36888, P43403, P51813, P54760, P97793, Q02763, Q04912, Q15046, Q16620, Q541P7, and Q9UM73

本数据集涵盖ALK酪氨酸激酶受体、Ephrin B型受体4（EphB4）、成纤维细胞生长因子受体1、肝细胞生长因子受体、胰岛素受体、JAK2/TYK2、驱动蛋白-1重链/酪氨酸蛋白激酶受体RET、赖氨酰-tRNA合成酶、巨噬细胞刺激蛋白受体、神经营养酪氨酸激酶受体2型、血小板衍生生长因子受体β、酪氨酸蛋白激酶SRC、酪氨酸蛋白激酶ABL1、酪氨酸蛋白激酶BMX、酪氨酸蛋白激酶JAK2、酪氨酸蛋白激酶ZAP-70、酪氨酸蛋白激酶受体FLT3、血管内皮生长因子受体2（VEGF-receptor 2）、酪氨酸蛋白激酶SRC、血管内皮生长因子受体、血管内皮生长因子受体2，以及血管内皮生长因子受体2与酪氨酸蛋白激酶TIE-2（即KDR与TIE2）的小分子结合数据，其对应UniProt（Uniprot）编号为L7RSL3、O60674、P00519、P06213、P07948、P07949、P08581、P09619、P11362、P12931、P15127、P17948、P29597、P35968、P36888、P43403、P51813、P54760、P97793、Q02763、Q04912、Q15046、Q16620、Q541P7及Q9UM73