Single-nucleotide polymorphism analysis (whole-exome sequencing) in patients with lumbar ligamentum flavum hypertrophy. Homo sapiens

The aim of this study is to investigate the mechanism underlying ligamentum flavum hypertrophy with genome-wide methods (whole-exome sequencing). We collected L4/5 ligamentum flavum samples from lumbar degeneration disease patients with or without ligamentum flavum hypertrophy (5 patients in each group) and performed single-nucleotide polymorphism analysis.