Additional file 1 of Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer

Additional file 1. Table S1: Comparison of breast cancer statuses in EGFR-mutated versus non-EGFR-mutated lung adenocarcinoma patients. Table S2. List of well-evidenced ClinVar null variants in genes with PVS1 variants. Table S3. List of ClinVar variants with the same amino acid change as PS1 variants. Table S4. List of ClinVar variants with the same modified residue as PM5 variants. Table S5. Pathogenicity predictions for various in silico prediction software for PP3 variants. Table S6. Frequency and Fisher's Exact Test results for three case cohorts and two control cohorts, for all pathogenic or likely pathogenic variants from this study. Table S7. Pathways of genes from all pathogenic and likely pathogenic variants in this study. Table S8. List of variants of uncertain significance and their corresponding ACMG/AMP criteria. Table S9. The number of variants of each type detected in each patient with dual primary breast and lung cancer. Table S10. Lack of association between the presence of pathogenic or likely pathogenic variants, and EGFR mutation statuses. Table S11: Cancers and cancer predisposition syndromes in ClinVar and their associated genes.