Neutral and Ionic Cycloruthenated 2‑Phenylindoles as Cytotoxic Agents
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The synthesis and characterization of two families of cyclometalated Ru(II) complexes with the new (Csp2,Nindole)− motif formed by activation of the C–H bonds of 2-phenylindole ligands of the general formula {(4′-R1-C6H4)-3-NOMe-5-R2-6-R3-(C6H2N)} are presented. The novel ruthenacycles show a remarkable cytotoxic activity in MCF7 and MDA-MB231 breast cancer cell lines, which clearly exceeds those of the trans and cis isomers of [PtCl2(L)(DMSO)] derived from the same ligands and even that of cisplatin.
创建时间：
2016-02-18
