Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.

Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. Descriptor: 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E Authors: Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. Deposit date: 2015-10-28 Release date: 2016-09-07 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016

真核翻译起始因子4E（eIF4E）与核苷酸模拟抑制剂的共晶结构。描述项：3-[[(2R,3S,4R,5R)-5-[2-氨基-7-[(3-氯苯基)甲基]-6-氧代-1H-嘌呤鎓-9-基]-3,4-二羟基四氢呋喃-2-基]甲氨基]-4-羟基环丁-3-烯-1,2-二酮、真核翻译起始因子4γ1（Eukaryotic translation initiation factor 4 gamma 1）、真核翻译起始因子4E。作者：Nowicki M.W.、Walkinshaw M.D.、Fischer P.M.。提交日期：2015-10-28；发布日期：2016-09-07；最后修改日期：2024-01-10。实验方法：X射线衍射（分辨率2.4埃）。引用文献：《翻译起始因子eIF4E的核苷酸模拟与非核苷酸抑制剂设计：合成、结构与功能表征》，《欧洲药物化学杂志》（Eur.J.Med.Chem.），第124卷，2016年。