Clinical, biological and genetic characterization of patients.

NA: not available.*Reference ranges for hormone levels and method characteristics. Total testosterone: 3.5–8.5 ng/mL for adult men (RIA, Orion Diagnostica device, Spectria®, Espoo, Finland; detection limit: 0.01 ng/mL; intra- and interassay coefficients of variation (CVs): 3.2% and 4.6%); estradiol: 15–35 pg/mL for men, 30 mU/mL for post-menopausal women; FSH: 1.4–10 mU/mL for men, >30 mU/mL for post-menopausal women (for LH and FSH: Immunotech device, Beckman Coulter, Praha, Czech Republic; detection limits: 0.1 IU/L for both FSH and LH; intra- and interassay CVs: **Subjective olfactometry was performed by a computed-assisted validated test [35].