CYGB dioxygenates NO

Cytosolic cytoglobin dimer, CYGB(Fe2+) catalyzes the reaction of O2 and NO to form NO3, converting CYBG(Fe2+) to CYBG(Fe3+) in the process (Gardner 2005; Gardner et al. 2010; Hamdane et al. 2003). For CYBG to function catalytically, its associated Fe3+ must be reduced to Fe2+ (Smagghe et al. 2008). This reduction can be efficiently mediated by ascorbate (Liu et al. 2013) and by CYB5B (cytochrome b5 type B) in vitro (Amdahl et al. 2017). The molecular details of the physiological reduction process remain unclear, so these entities are annotated as positive regulators of the dioxygenation reaction catalyzed by CYGB.<br>

细胞质细胞球蛋白二聚体CYGB(Fe2+)催化氧气和一氧化氮的反应生成亚硝酸盐，在此过程中将CYGB(Fe2+)转化为CYGB(Fe3+)（Gardner 2005；Gardner等2010；Hamdane等2003）。为了使CYGB能够催化反应，其相关的Fe3+必须还原为Fe2+（Smagghe等2008）。这种还原过程可以通过抗坏血酸（Liu等2013）以及在体外由细胞色素b5型B（CYB5B）有效地介导（Amdahl等2017）。关于生理还原过程的分子细节尚不明确，因此这些实体被标注为由CYGB催化的氧合反应的正向调节因子。