Excitability of mouse hippocampal CA1 pyramidal neurons during sustained (500 ms) strong depolarization (v1)

In this work, we highlight an electrophysiological feature often observed in recordings from mouse CA1 pyramidal cells that has so far been ignored by experimentalists and modelers. It consists of a large and dynamic increase in the depolarization baseline (i.e., the minimum value of the membrane potential between successive action potentials during a sustained depolarizing input) in response to strong somatic current injections. Such an increased sustained depolarization can directly affect neurotransmitter release properties and, more generally, the efficacy of synaptic transmission. However, it cannot be explained by any currently available conductance-based computational model. Here, we provide the original data describing and modeling the depolarization baseline (DBL) phenomenon and descriptions of the methods used, as reported in the related publication (Bianchi et al., 2022). This dataset entails the experiments generated in laboratory 2.