Cryo-EM structure of rhesus antibody CH35-Apex1.08 in complex with HIV Env trimer Q23-APEX-GT2

Cryo-EM structure of rhesus antibody CH35-Apex1.08 in complex with HIV Env trimer Q23-APEX-GT2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH35-Apex1.08 heavy chain, ... Authors: Roark, R.S, Shapiro, L.S, Kwong, P.D. Deposit date: 2025-03-21 Release date: 2026-04-01 Last modified: 2026-04-29 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques. Immunity, 59, 2026冷冻电镜（Cryo-EM）结构：与HIV包膜蛋白Env三聚体Q23-APEX-GT2结合的恒河猴抗体CH35-Apex1.08 描述：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、CH35-Apex1.08重链…… 作者：Roark, R.S.、Shapiro, L.S.、Kwong, P.D. 存档日期：2025-03-21 发布日期：2026-04-01 最后修改日期：2026-04-29 实验方法：电子显微镜（分辨率3.3 Å） 引用文献：种系靶向HIV免疫原在远交系猕猴中诱导交叉中和抗体。《免疫》（Immunity），59卷，2026年