Fkbp5 rs1360780 x Early Life Adversity Mouse Model Validation
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https://www.ncbi.nlm.nih.gov/sra/SRP326653
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资源简介：
The cumulative load of genetic predisposition, early life adversity (ELA) and lifestyle shapes the prevalence of psychiatric disorders. Single nucleotide polymorphisms (SNPs) in the human FKBP5 gene were shown to modulate disease risk. To enable investigation of disease-related SNPs in behaviorally relevant context, we generated humanized mouse lines carrying either the risk (AT) or the resiliency (CG) allele of the rs1360780 locus and exposed litters of these mice to maternal separation.Differential expression of genes in brain regions that are regulating the stress response were enriched for pathways related to synaptic transmission, metabolism, and circadian entrainment. Our data suggest an integrative role ofFKBP5 in shaping the sex-specific outcome of ELA in adulthood.
创建时间：
2021-09-28
