Mechanisms of Th17 and Treg cell dysregulation in oral mucosal inflammation during HIV disease

Purpose: The goal of this study is to compare the transcriptomic profiles of healthy individuals and HIV+ patients on therapy Methods: Cells were pelleted from gingival mucosa. mRNA profiles were generated by Next-gen sequencing using the Illumina platform. Results: Comprehensive transcriptome data that showed underlying changes in the oral mucosal immune system of HIV+ patients on therapy. The transcriptome data of the pooled healthy controls are presented here. Conclusions: Our study represents the analysis of oral gingival transcriptomes. We conclude that RNA-seq based transcriptome characterization would expedite genetic network analyses and permit the dissection of complex biological functional alterations during chronic viral infections such as HIV infection. Oral mucosal gingival cell mRNA profiles ex vivo of control (healthy) and HIV+ patients on therapy (HIV + cART)