Anti-cancer Mechanism of MS17 [1, 5-bis (2-hydroxyphenyl)-1, 4-pentadiene-3-one] and Curcumin-treated Human Glioblastoma and Neuroblastoma Cells

Glioblastoma and neuroblastoma are malignant tumors of the brain and central nervous system. Current treatment options are limited to treating these malignancies. There is a need to find new adjuvants to combat these cancers. Natural products and their derivatives are promising anticancer agents because of their broad pharmacological activities. Curcumin has shown remarkable anticancer effects against various cancers by targeting many molecular targets in cancer development. Curcumin analogs such as diarylpentanoids (e.g., MS17) are emerging anticancer agents. MS17 has shown potent cell growth inhibitory effects in in-vitro studies.