Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase Descriptor: CHLORIDE ION, N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, ... Authors: Baker, L.M, Brough, P, Surgenor, A. Deposit date: 2016-10-18 Release date: 2017-02-22 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase. J. Med. Chem., 60, 2017解离速率筛选（Off-Rate Screening）在丙酮酸脱氢酶激酶（Pyruvate Dehydrogenase Kinase）新型泛亚型抑制剂（Pan-Isoform Inhibitors）发现中的应用 描述项：氯离子、N-(2-氨基乙基)-2-{3-氯-4-[(4-异丙基苄基)氧基]苯基}乙酰胺、[丙酮酸脱氢酶（乙酰基转移酶）（Pyruvate dehydrogenase (acetyl-transferring)）]激酶同工型2，…… 作者：Baker, L.M.、Brough, P.、Surgenor, A. 入库日期：2016-10-18 发布日期：2017-02-22 最后修改时间：2024-01-17 实验方法：X射线衍射（分辨率2.3埃） 引用：解离速率筛选在丙酮酸脱氢酶激酶新型泛亚型抑制剂发现中的应用，J. Med. Chem., 60, 2017