Transcriptomic study of NR8383 cells following exposure to zinc oxide nanoparticles NM110. Rattus norvegicus

To identify differentially expressed genes and key biological pathways that define toxicity following nanoparticle exposure, we performed microarray analyses on NR8383 macrophages exposed for 4 h to 2 µg/mL of NP ZnO (20 % cell viability). This project (SmartNanoTox) has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 686098. Overall design: Changes in gene expression in NR8383 cells incubated without (control) or with (2 µg/mL) of NP ZnO for 4 h were measured. For each condition, three biological replicates, at less, were performed : C1; C2; C3; C4 as controls, Z1; Z2; Z3, as exposed cells to 2 µg/mL respectively.