Identification of differentially expressed genes in cisplatin-resistant and parental esophageal squamous cell carcinoma cells

Drug resistance remains a main obstacle for cancer treatment. To reveal differentially expressed genes in chemoresistant cells, we established two pairs of resistant/parental esophageal squamous cell carcinoma (ESCC) cell lines, and performed whole transcriptome sequencing to identify both coding and noncoding RNAs that are significantly changed in chemoresistant cells. We identidied several important genes that contribute to the resistance of ESCC cells to chemotherapies. Whole transcriptome sequencing of KYSE450/DDP, KYSE450, YES2/DDP and YES2 cell lines. Two replicates for each arm.